Fetal Movement Counting in Prolonged Pregnancies: The COMPTAMAF Prospective Randomized Trial.
Louise MoniodAgathe HovineBéatrice TrombertFlorence RanconPaul ZuffereyLaura ChauveauCéline ChauleurTiphaine Raia-BarjatPublished in: Healthcare (Basel, Switzerland) (2022)
In prolonged pregnancies, the risks of neonatal morbidity and mortality are increased. The aim of this trial was to assess the benefits of maternal information about fetal movement (FM) counting on neonatal outcomes in prolonged pregnancy. It was a prospective, single center, randomized, open-label study conducted from October 2019 to March 2022. Intention-to-treat analyses were performed on 278 patients randomized into two 1:1 groups (control group and FM counting group). The primary outcome was a composite score of neonatal morbidity (presence of two of the following items: fetal heart rate abnormality at delivery, Apgar score of <7 at 5 min, umbilical cord arterial pH of <7.20, and acute respiratory distress with mutation in neonatal intensive care unit). There was no significant difference between the two groups in the rate of neonatal morbidity (14.0% in the FM counting group versus 22.9% in the standard information group; p = 0.063; OR 0.55, 95% CI 0.29−1.0). In this study, fetal movement counting for women in prolonged pregnancy failed to demonstrate a significant reduction in adverse neonatal outcomes.
Keyphrases
- open label
- pregnancy outcomes
- heart rate
- phase iii
- phase ii
- preterm birth
- umbilical cord
- mesenchymal stem cells
- clinical trial
- double blind
- end stage renal disease
- heart rate variability
- blood pressure
- placebo controlled
- ejection fraction
- chronic kidney disease
- newly diagnosed
- healthcare
- squamous cell carcinoma
- health information
- randomized controlled trial
- polycystic ovary syndrome
- liver failure
- type diabetes
- climate change
- metabolic syndrome
- social media
- body mass index
- insulin resistance
- intensive care unit
- adipose tissue
- bone marrow
- electronic health record
- mechanical ventilation
- respiratory failure