Hepatocyte growth factor pretreatment boosts functional recovery after spinal cord injury through human iPSC-derived neural stem/progenitor cell transplantation.

Yu SuematsuNarihito NagoshiMunehisa ShinozakiYoshitaka KaseYusuke SaijoShogo HashimotoTakahiro ShibataKeita KajikawaYasuhiro KamataMasahiro OzakiKaori YasutakeTomoko ShindoShinsuke ShibataMorio MatsumotoMasaya NakamuraHideyuki Okano

Published in: Inflammation and regeneration (2023)

We demonstrate that the combined therapeutic approach of HGF preconditioning and hiPSC-NS/PC transplantation enhances locomotor functional recovery post-SCI, highlighting a highly promising therapeutic strategy for acute to subacute SCI.

Keyphrases

growth factor
spinal cord injury
induced pluripotent stem cells
endothelial cells
liver failure
cell therapy
respiratory failure
drug induced
intensive care unit
hepatitis b virus
zika virus
cerebral ischemia
brain injury
acute respiratory distress syndrome
mechanical ventilation