Hideyuki Okano

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 118

Top Venues

Communications biology

Inflammation and regeneration

Cells

eNeuro

Keio University School of Medicne

Keio University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Keio University School of Medicne Apr 01 2001

Japan

Dean and Professor :: Department of Physiology

Education History

Keio University

Japan

PHD :: Department of Physiology, School of Medicine

Publications

Takeshi Kaizuka, Takehiro Suzuki, Noriyuki Kishi, Kota Tamada, Manfred W Kilimann, Takehiko Ueyama, Masahiko Watanabe, Tomomi Shimogori, Hideyuki Okano, Naoshi Dohmae, Toru Takumi
Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development. Nature communications 15 (1) (2024)
Rei Murakami, Hirotaka Watanabe, Hideko Hashimoto, Mayu Kashiwagi-Hakozaki, Tadafumi Hashimoto, Celeste M Karch, null null, Takeshi Iwatsubo, Hideyuki Okano
Inhibitory Roles of Apolipoprotein E Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived Models. The Journal of neuroscience : the official journal of the Society for Neuroscience 44 (24) (2024)
Saori Yano-Nashimoto, Anna Truzzi, Kazutaka Shinozuka, Ayako Y Murayama, Takuma Kurachi, Keiko Moriya-Ito, Hironobu Tokuno, Eri Miyazawa, Gianluca Esposito, Hideyuki Okano, Katsuki Nakamura, Atsuko Saito, Kumi O Kuroda
Anxious about rejection, avoidant of neglect: Infant marmosets tune their attachment based on individual caregiver's parenting style. Communications biology 7 (1) (2024)
Sopak Supakul, Rei Murakami, Chisato Oyama, Tomoko Shindo, Yuki Hatakeyama, Maika Itsuno, Hiroko Bannai, Shinsuke Shibata, Sumihiro Maeda, Hideyuki Okano
Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer's disease. Inflammation and regeneration 44 (1) (2024)
Sopak Supakul, Rei Murakami, Chisato Oyama, Tomoko Shindo, Yuki Hatakeyama, Maika Itsuno, Hiroko Bannai, Shinsuke Shibata, Sumihiro Maeda, Hideyuki Okano
Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer's disease. Inflammation and regeneration 44 (1) (2024)
Syoichi Tashiro, Shinsuke Shibata, Narihito Nagoshi, Liang Zhang, Shin Yamada, Tetsuya Tsuji, Masaya Nakamura, Hideyuki Okano
Do Pharmacological Treatments Act in Collaboration with Rehabilitation in Spinal Cord Injury Treatment? A Review of Preclinical Studies. Cells 13 (5) (2024)
Takayuki Nishijima, Kentaro Okuyama, Shinsuke Shibata, Hiroo Kimura, Munehisa Shinozaki, Takehito Ouchi, Yo Mabuchi, Tatsukuni Ohno, Junpei Nakayama, Manabu Hayatsu, Keiko Uchiyama, Tomoko Shindo, Eri Niiyama, Sayaka Toita, Jiro Kawada, Takuji Iwamoto, Masaya Nakamura, Hideyuki Okano, Narihito Nagoshi
Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury. Inflammation and regeneration 44 (1) (2024)
Takeshi Kaizuka, Takehiro Suzuki, Noriyuki Kishi, Kota Tamada, Manfred W Kilimann, Takehiko Ueyama, Masahiko Watanabe, Tomomi Shimogori, Hideyuki Okano, Naoshi Dohmae, Toru Takumi
Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development. Nature communications 15 (1) (2024)
Hidenori Homma, Yuki Yoshioka, Kyota Fujita, Shinichi Shirai, Yuka Hama, Hajime Komano, Yuko Saito, Ichiro Yabe, Hideyuki Okano, Hidenao Sasaki, Hikari Tanaka, Hitoshi Okazawa
Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. Communications biology 7 (1) (2024)
Hidenori Homma, Yuki Yoshioka, Kyota Fujita, Shinichi Shirai, Yuka Hama, Hajime Komano, Yuko Saito, Ichiro Yabe, Hideyuki Okano, Hidenao Sasaki, Hikari Tanaka, Hitoshi Okazawa
Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. Communications biology 7 (1) (2024)
Yuji Okano, Yoshitaka Kase, Yu Suematsu, Masaya Nakamura, Hideyuki Okano
Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue. Inflammation and regeneration 44 (1) (2024)
Hidenori Homma, Yuki Yoshioka, Kyota Fujita, Shinichi Shirai, Yuka Hama, Hajime Komano, Yuko Saito, Ichiro Yabe, Hideyuki Okano, Hidenao Sasaki, Hikari Tanaka, Hitoshi Okazawa
Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. Communications biology 7 (1) (2024)
Nicolas Leventoux, Satoru Morimoto, Mitsuru Ishikawa, Shiho Nakamura, Fumiko Ozawa, Reona Kobayashi, Hirotaka Watanabe, Sopak Supakul, Satoshi Okamoto, Zhi Zhou, Hiroya Kobayashi, Chris Kato, Yoshifumi Hirokawa, Ikuko Aiba, Shinichi Takahashi, Shinsuke Shibata, Masaki Takao, Mari Yoshida, Fumito Endo, Koji Yamanaka, Yasumasa Kokubo, Hideyuki Okano
Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes. Acta neuropathologica 147 (1) (2024)
Yuji Okano, Yoshitaka Kase, Yu Suematsu, Masaya Nakamura, Hideyuki Okano
Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue. Inflammation and regeneration 44 (1) (2024)
Saori Yano-Nashimoto, Anna Truzzi, Kazutaka Shinozuka, Ayako Y Murayama, Takuma Kurachi, Keiko Moriya-Ito, Hironobu Tokuno, Eri Miyazawa, Gianluca Esposito, Hideyuki Okano, Katsuki Nakamura, Atsuko Saito, Kumi O Kuroda
Anxious about rejection, avoidant of neglect: Infant marmosets tune their attachment based on individual caregiver's parenting style. Communications biology 7 (1) (2024)
Yonehiro Kanemura, Atsuyo Yamamoto, Asako Katsuma, Hayato Fukusumi, Tomoko Shofuda, Daisuke Kanematsu, Yukako Handa, Miho Sumida, Ema Yoshioka, Yutaka Mine, Ryo Yamaguchi, Masayasu Okada, Michihiro Igarashi, Yuko Sekino, Tomoaki Shirao, Masaya Nakamura, Hideyuki Okano
Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Formation of Synaptic Structures in Rodent Ischemic Stroke Brains. Cells 13 (8) (2024)
Syoichi Tashiro, Shinsuke Shibata, Narihito Nagoshi, Liang Zhang, Shin Yamada, Tetsuya Tsuji, Masaya Nakamura, Hideyuki Okano
Do Pharmacological Treatments Act in Collaboration with Rehabilitation in Spinal Cord Injury Treatment? A Review of Preclinical Studies. Cells 13 (5) (2024)
Chris Kato, Yasumasa Kokubo, Shinichi Takahashi, Shinichi Namba, Qingbo S Wang, Yukinori Okada, Hideyuki Okano
Spinal cord motor neuron phenotypes and polygenic risk scores in sporadic amyotrophic lateral sclerosis: deciphering the disease pathology and therapeutic potential of ropinirole hydrochloride. Journal of neurology, neurosurgery, and psychiatry (2024)
Takashi Yoshida, Syoichi Tashiro, Narihito Nagoshi, Munehisa Shinozaki, Takahiro Shibata, Mitsuhiro Inoue, Shoji Ogawa, Shinsuke Shibata, Tetsuya Tsuji, Hideyuki Okano, Masaya Nakamura
Chronic Spinal Cord Injury Regeneration with Combined Therapy Comprising Neural Stem/Progenitor Cell Transplantation, Rehabilitation, and Semaphorin 3A Inhibitor. eNeuro 11 (2) (2024)
Rei Murakami, Hirotaka Watanabe, Hideko Hashimoto, Mayu Kashiwagi-Hakozaki, Tadafumi Hashimoto, Celeste M Karch, null null, Takeshi Iwatsubo, Hideyuki Okano
Inhibitory Roles of Apolipoprotein E Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived Models. The Journal of neuroscience : the official journal of the Society for Neuroscience 44 (24) (2024)
Takashi Yoshida, Syoichi Tashiro, Narihito Nagoshi, Munehisa Shinozaki, Takahiro Shibata, Mitsuhiro Inoue, Shoji Ogawa, Shinsuke Shibata, Tetsuya Tsuji, Hideyuki Okano, Masaya Nakamura
Chronic Spinal Cord Injury Regeneration with Combined Therapy Comprising Neural Stem/Progenitor Cell Transplantation, Rehabilitation, and Semaphorin 3A Inhibitor. eNeuro 11 (2) (2024)
Nicolas Leventoux, Satoru Morimoto, Mitsuru Ishikawa, Shiho Nakamura, Fumiko Ozawa, Reona Kobayashi, Hirotaka Watanabe, Sopak Supakul, Satoshi Okamoto, Zhi Zhou, Hiroya Kobayashi, Chris Kato, Yoshifumi Hirokawa, Ikuko Aiba, Shinichi Takahashi, Shinsuke Shibata, Masaki Takao, Mari Yoshida, Fumito Endo, Koji Yamanaka, Yasumasa Kokubo, Hideyuki Okano
Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes. Acta neuropathologica 147 (1) (2024)
Hidenori Homma, Yuki Yoshioka, Kyota Fujita, Shinichi Shirai, Yuka Hama, Hajime Komano, Yuko Saito, Ichiro Yabe, Hideyuki Okano, Hidenao Sasaki, Hikari Tanaka, Hitoshi Okazawa
Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. Communications biology 7 (1) (2024)
Rei Murakami, Hirotaka Watanabe, Hideko Hashimoto, Mayu Kashiwagi-Hakozaki, Tadafumi Hashimoto, Celeste M Karch, null null, Takeshi Iwatsubo, Hideyuki Okano
Inhibitory Roles of Apolipoprotein E Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived Models. The Journal of neuroscience : the official journal of the Society for Neuroscience 44 (24) (2024)
Takayuki Nishijima, Kentaro Okuyama, Shinsuke Shibata, Hiroo Kimura, Munehisa Shinozaki, Takehito Ouchi, Yo Mabuchi, Tatsukuni Ohno, Junpei Nakayama, Manabu Hayatsu, Keiko Uchiyama, Tomoko Shindo, Eri Niiyama, Sayaka Toita, Jiro Kawada, Takuji Iwamoto, Masaya Nakamura, Hideyuki Okano, Narihito Nagoshi
Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury. Inflammation and regeneration 44 (1) (2024)
Takashi Yoshida, Syoichi Tashiro, Narihito Nagoshi, Munehisa Shinozaki, Takahiro Shibata, Mitsuhiro Inoue, Shoji Ogawa, Shinsuke Shibata, Tetsuya Tsuji, Hideyuki Okano, Masaya Nakamura
Chronic Spinal Cord Injury Regeneration with Combined Therapy Comprising Neural Stem/Progenitor Cell Transplantation, Rehabilitation, and Semaphorin 3A Inhibitor. eNeuro 11 (2) (2024)
Yuji Okano, Yoshitaka Kase, Yu Suematsu, Masaya Nakamura, Hideyuki Okano
Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue. Inflammation and regeneration 44 (1) (2024)
Yoshika Hayakawa-Yano, Takako Furukawa, Tsuyoshi Matsuo, Takahisa Ogasawara, Masahiro Nogami, Kazumasa Yokoyama, Masato Yugami, Munehisa Shinozaki, Chihiro Nakamoto, Kenji Sakimura, Akihide Koyama, Kazuhiro Ogi, Osamu Onodera, Hirohide Takebayashi, Hideyuki Okano, Masato Yano
Qki5 safeguards spinal motor neuron function by defining the motor neuron-specific transcriptome via pre-mRNA processing. Proceedings of the National Academy of Sciences of the United States of America 121 (37) (2024)
Chris Kato, Koji Ueda, Satoru Morimoto, Shinichi Takahashi, Shiho Nakamura, Fumiko Ozawa, Daisuke Ito, Yugaku Daté, Kensuke Okada, Naoki Kobayashi, Jin Nakahara, Hideyuki Okano
Proteomic insights into extracellular vesicles in ALS for therapeutic potential of Ropinirole and biomarker discovery. Inflammation and regeneration 44 (1) (2024)
Rei Murakami, Hirotaka Watanabe, Hideko Hashimoto, Mayu Kashiwagi-Hakozaki, Tadafumi Hashimoto, Celeste M Karch, null null, Takeshi Iwatsubo, Hideyuki Okano
Inhibitory Roles of Apolipoprotein E Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived Models. The Journal of neuroscience : the official journal of the Society for Neuroscience 44 (24) (2024)
Saori Yano-Nashimoto, Anna Truzzi, Kazutaka Shinozuka, Ayako Y Murayama, Takuma Kurachi, Keiko Moriya-Ito, Hironobu Tokuno, Eri Miyazawa, Gianluca Esposito, Hideyuki Okano, Katsuki Nakamura, Atsuko Saito, Kumi O Kuroda
Anxious about rejection, avoidant of neglect: Infant marmosets tune their attachment based on individual caregiver's parenting style. Communications biology 7 (1) (2024)
Yonehiro Kanemura, Atsuyo Yamamoto, Asako Katsuma, Hayato Fukusumi, Tomoko Shofuda, Daisuke Kanematsu, Yukako Handa, Miho Sumida, Ema Yoshioka, Yutaka Mine, Ryo Yamaguchi, Masayasu Okada, Michihiro Igarashi, Yuko Sekino, Tomoaki Shirao, Masaya Nakamura, Hideyuki Okano
Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Formation of Synaptic Structures in Rodent Ischemic Stroke Brains. Cells 13 (8) (2024)
Syoichi Tashiro, Shinsuke Shibata, Narihito Nagoshi, Liang Zhang, Shin Yamada, Tetsuya Tsuji, Masaya Nakamura, Hideyuki Okano
Do Pharmacological Treatments Act in Collaboration with Rehabilitation in Spinal Cord Injury Treatment? A Review of Preclinical Studies. Cells 13 (5) (2024)
Takeshi Kaizuka, Takehiro Suzuki, Noriyuki Kishi, Kota Tamada, Manfred W Kilimann, Takehiko Ueyama, Masahiko Watanabe, Tomomi Shimogori, Hideyuki Okano, Naoshi Dohmae, Toru Takumi
Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development. Nature communications 15 (1) (2024)
Nicolas Leventoux, Satoru Morimoto, Mitsuru Ishikawa, Shiho Nakamura, Fumiko Ozawa, Reona Kobayashi, Hirotaka Watanabe, Sopak Supakul, Satoshi Okamoto, Zhi Zhou, Hiroya Kobayashi, Chris Kato, Yoshifumi Hirokawa, Ikuko Aiba, Shinichi Takahashi, Shinsuke Shibata, Masaki Takao, Mari Yoshida, Fumito Endo, Koji Yamanaka, Yasumasa Kokubo, Hideyuki Okano
Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes. Acta neuropathologica 147 (1) (2024)
Nicolas Leventoux, Satoru Morimoto, Mitsuru Ishikawa, Shiho Nakamura, Fumiko Ozawa, Reona Kobayashi, Hirotaka Watanabe, Sopak Supakul, Satoshi Okamoto, Zhi Zhou, Hiroya Kobayashi, Chris Kato, Yoshifumi Hirokawa, Ikuko Aiba, Shinichi Takahashi, Shinsuke Shibata, Masaki Takao, Mari Yoshida, Fumito Endo, Koji Yamanaka, Yasumasa Kokubo, Hideyuki Okano
Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes. Acta neuropathologica 147 (1) (2024)
Takayuki Nishijima, Kentaro Okuyama, Shinsuke Shibata, Hiroo Kimura, Munehisa Shinozaki, Takehito Ouchi, Yo Mabuchi, Tatsukuni Ohno, Junpei Nakayama, Manabu Hayatsu, Keiko Uchiyama, Tomoko Shindo, Eri Niiyama, Sayaka Toita, Jiro Kawada, Takuji Iwamoto, Masaya Nakamura, Hideyuki Okano, Narihito Nagoshi
Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury. Inflammation and regeneration 44 (1) (2024)
Yonehiro Kanemura, Atsuyo Yamamoto, Asako Katsuma, Hayato Fukusumi, Tomoko Shofuda, Daisuke Kanematsu, Yukako Handa, Miho Sumida, Ema Yoshioka, Yutaka Mine, Ryo Yamaguchi, Masayasu Okada, Michihiro Igarashi, Yuko Sekino, Tomoaki Shirao, Masaya Nakamura, Hideyuki Okano
Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Formation of Synaptic Structures in Rodent Ischemic Stroke Brains. Cells 13 (8) (2024)
Saori Yano-Nashimoto, Anna Truzzi, Kazutaka Shinozuka, Ayako Y Murayama, Takuma Kurachi, Keiko Moriya-Ito, Hironobu Tokuno, Eri Miyazawa, Gianluca Esposito, Hideyuki Okano, Katsuki Nakamura, Atsuko Saito, Kumi O Kuroda
Anxious about rejection, avoidant of neglect: Infant marmosets tune their attachment based on individual caregiver's parenting style. Communications biology 7 (1) (2024)
Hidenori Homma, Yuki Yoshioka, Kyota Fujita, Shinichi Shirai, Yuka Hama, Hajime Komano, Yuko Saito, Ichiro Yabe, Hideyuki Okano, Hidenao Sasaki, Hikari Tanaka, Hitoshi Okazawa
Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. Communications biology 7 (1) (2024)
Chris Kato, Koji Ueda, Satoru Morimoto, Shinichi Takahashi, Shiho Nakamura, Fumiko Ozawa, Daisuke Ito, Yugaku Daté, Kensuke Okada, Naoki Kobayashi, Jin Nakahara, Hideyuki Okano
Proteomic insights into extracellular vesicles in ALS for therapeutic potential of Ropinirole and biomarker discovery. Inflammation and regeneration 44 (1) (2024)
Takahiro Shibata, Syoichi Tashiro, Masaya Nakamura, Hideyuki Okano, Narihito Nagoshi
A Review of Treatment Methods Focusing on Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation for Chronic Spinal Cord Injury. Medicina (Kaunas, Lithuania) 59 (7) (2023)
Tosho Kondo, Ihori Ebinuma, Hirotaka Tanaka, Yukitoshi Nishikawa, Takaki Komiya, Mitsuru Ishikawa, Hideyuki Okano
Rapid and Robust Multi-Phenotypic Assay System for ALS Using Human iPS Cells with Mutations in Causative Genes. International journal of molecular sciences 24 (8) (2023)
Takahiro Shibata, Syoichi Tashiro, Shinsuke Shibata, Munehisa Shinozaki, Tomoko Shindo, Shogo Hashimoto, Momotaro Kawai, Takahiro Kitagawa, Kentaro Ago, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano, Narihito Nagoshi
Rehabilitative Training Enhances Therapeutic Effect of Human-iPSC-Derived Neural Stem/Progenitor Cells Transplantation in Chronic Spinal Cord Injury. Stem cells translational medicine (2023)
Hiroya Kobayashi, Koji Ueda, Yasumasa Kokubo, Mitsuru Ishikawa, Nicolas Leventoux, Ryogen Sasaki, Yoshifumi Hirokawa, Yasumasa Kokubo, Hideyuki Okano
Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)
Hitomi Ono Minagi, Tsutomu Nohno, Takashi Serizawa, Yu Usami, Takayoshi Sakai, Hideyuki Okano, Hideyo Ohuchi
The Germinal Origin of Salivary and Lacrimal Glands and the Contributions of Neural Crest Cell-Derived Epithelium to Tissue Regeneration. International journal of molecular sciences 24 (18) (2023)
Takuma Kurachi, Kazutaka Shinozuka, Chihiro Yoshihara, Saori Yano-Nashimoto, Ayako Y Murayama, Junichi Hata, Yawara Haga, Hideyuki Okano, Kumi O Kuroda
Distinct roles of amylin and oxytocin signaling in intrafamilial social behaviors at the medial preoptic area of common marmosets. Communications biology 6 (1) (2023)
Ryotaro Imai, Masahiro Toda, Masahiro Yo, Mizuto Sato, Mariko Fukumura, Kento Takahara, Yoshitaka Kase, Hideyuki Okano, Masahiro Toda
Neuroprotective effects of genome-edited human iPS cell-derived neural stem/progenitor cells on traumatic brain injury. Stem cells (Dayton, Ohio) (2023)
Hideyuki Okano, Satoru Morimoto, Chris Kato, Jin Nakahara, Shinichi Takahashi
Induced pluripotent stem cells-based disease modeling, drug screening, clinical trials, and reverse translational research for amyotrophic lateral sclerosis. Journal of neurochemistry (2023)
Yu Suematsu, Narihito Nagoshi, Munehisa Shinozaki, Yoshitaka Kase, Yusuke Saijo, Shogo Hashimoto, Takahiro Shibata, Keita Kajikawa, Yasuhiro Kamata, Masahiro Ozaki, Kaori Yasutake, Tomoko Shindo, Shinsuke Shibata, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano
Hepatocyte growth factor pretreatment boosts functional recovery after spinal cord injury through human iPSC-derived neural stem/progenitor cell transplantation. Inflammation and regeneration 43 (1) (2023)
Miho Isoda, Tsukasa Sanosaka, Ryo Tomooka, Yo Mabuchi, Munehisa Shinozaki, Tomoko Andoh-Noda, Satoe Banno, Noriko Mizota, Ryo Yamaguchi, Hideyuki Okano, Jun Kohyama
Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation. Communications biology 6 (1) (2023)
Dan Li, Yoshikazu Johmura, Satoru Morimoto, Miyuki Doi, Keiko Nakanishi, Manabu Ozawa, Yuji Tsunekawa, Akane Inoue-Yamauchi, Hiroya Naruse, Takashi Matsukawa, Yukio Takeshita, Naoki Suzuki, Masashi Aoki, Ayumi Nishiyama, Xin Zeng, Chieko Konishi, Narumi Suzuki, Atsuya Nishiyama, Alexander Stephen Harris, Mariko Morita, Kiyoshi Yamaguchi, Yoichi Furukawa, Kenta Nakai, Shoji Tsuji, Satoshi Yamazaki, Yuji Yamanashi, Shoichi Shimada, Takashi Okada, Hideyuki Okano, Tatsushi Toda, Makoto Nakanishi
LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits. Nature aging (2023)
Yasuyuki Shima, Shota Sasagawa, Nakao Ota, Rieko Oyama, Minoru Tanaka, Mie Kubota-Sakashita, Hirochika Kawakami, Mika Kobayashi, Naoko Takubo, Atsuko Nakanishi Ozeki, Xiaoning Sun, Yeon-Jeong Kim, Yoichiro Kamatani, Koichi Matsuda, Kazuhiro Maejima, Masashi Fujita, Kosumo Noda, Hiroyasu Kamiyama, Rokuya Tanikawa, Motoo Nagane, Junji Shibahara, Toru Tanaka, Yoshiyuki Rikitake, Nobuko Mataga, Satoru Takahashi, Kenjiro Kosaki, Hideyuki Okano, Tomomi Furihata, Ryo Nakaki, Nobuyoshi Akimitsu, Youichiro Wada, Toshihisa Ohtsuka, Hiroki Kurihara, Hiroyuki Kamiguchi, Shigeo Okabe, Masato Nakafuku, Tadafumi Kato, Hidewaki Nakagawa, Nobuhito Saito, Hirofumi Nakatomi
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms. Science translational medicine 15 (700) (2023)
Takahiro Shibata, Syoichi Tashiro, Shinsuke Shibata, Munehisa Shinozaki, Tomoko Shindo, Shogo Hashimoto, Momotaro Kawai, Takahiro Kitagawa, Kentaro Ago, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano, Narihito Nagoshi
Rehabilitative Training Enhances Therapeutic Effect of Human-iPSC-Derived Neural Stem/Progenitor Cells Transplantation in Chronic Spinal Cord Injury. Stem cells translational medicine 12 (2) (2023)
Yoshimi Kawamura, Kaori Oka, Takashi Semba, Mayuko Takamori, Yuki Sugiura, Riyo Yamasaki, Yusuke Suzuki, Takeshi Chujo, Mari Nagase, Yuki Oiwa, Shusuke Fujioka, Sayuri Homma, Yuki Yamamura, Shingo Miyawaki, Minoru Narita, Takaichi Fukuda, Yusuke Sakai, Takatsugu Ishimoto, Kazuhito Tomizawa, Makoto Suematsu, Takuya Yamamoto, Hidemasa Bono, Hideyuki Okano, Kyoko Miura
Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats. The EMBO journal (2023)
Tosho Kondo, Ihori Ebinuma, Hirotaka Tanaka, Yukitoshi Nishikawa, Takaki Komiya, Mitsuru Ishikawa, Hideyuki Okano
Rapid and Robust Multi-Phenotypic Assay System for ALS Using Human iPS Cells with Mutations in Causative Genes. International journal of molecular sciences 24 (8) (2023)
Takahito Iga, Hiroshi Kobayashi, Dai Kusumoto, Tsukasa Sanosaka, Nobuyuki Fujita, Ikue Tai-Nagara, Tomofumi Ando, Tomoko Takahashi, Koichi Matsuo, Katsuto Hozumi, Kosei Ito, Masatsugu Ema, Takeshi Miyamoto, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano, Shinsuke Shibata, Jun Kohyama, Kevin K Kim, Keiyo Takubo, Yoshiaki Kubota
Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis. Nature cell biology (2023)
Tosho Kondo, Ihori Ebinuma, Hirotaka Tanaka, Yukitoshi Nishikawa, Takaki Komiya, Mitsuru Ishikawa, Hideyuki Okano
Rapid and Robust Multi-Phenotypic Assay System for ALS Using Human iPS Cells with Mutations in Causative Genes. International journal of molecular sciences 24 (8) (2023)
Emi Qian, Masahiro Uemura, Hiroya Kobayashi, Shiho Nakamura, Fumiko Ozawa, Sho Yoshimatsu, Mitsuru Ishikawa, Osamu Onodera, Satoru Morimoto, Hideyuki Okano
A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation in HTRA1. Inflammation and regeneration 43 (1) (2023)
Takaaki Kaneko, Misako Komatsu, Tetsuo Yamamori, Noritaka Ichinohe, Hideyuki Okano
Cortical neural dynamics unveil the rhythm of natural visual behavior in marmosets. Communications biology 5 (1) (2022)
Tomoko Matsubara, Takahito Iga, Yuki Sugiura, Dai Kusumoto, Tsukasa Sanosaka, Ikue Tai-Nagara, Norihiko Takeda, Guo-Hua Fong, Kosei Ito, Masatsugu Ema, Hideyuki Okano, Jun Kohyama, Makoto Suematsu, Yoshiaki Kubota
Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice. The Journal of experimental medicine 219 (4) (2022)
Yukina Morimoto, Ayako Tokumitsu, Takefumi Sone, Yuki Hirota, Ryota Tamura, Ayuna Sakamoto, Kazunori Nakajima, Masahiro Toda, Yutaka Kawakami, Hideyuki Okano, Shigeki Ohta
TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF). Neurochemical research 47 (9) (2022)
Tao Lu, Munehisa Shinozaki, Narihito Nagoshi, Masaya Nakamura, Hideyuki Okano
Long Preservation of AAV-Transduced Fluorescence by a Modified Organic Solvent-Based Clearing Method. International journal of molecular sciences 23 (17) (2022)
Satoru Morimoto, Koichi Saeki, Masaru Takeshita, Kunio Hirano, Mariko Shirakawa, Yumiko Yamada, Shiho Nakamura, Fumiko Ozawa, Hideyuki Okano
Intranasal Sendai virus-based SARS-CoV-2 vaccine using a mouse model. Genes to cells : devoted to molecular & cellular mechanisms (2022)
Sho Yoshimatsu, Atsushi Yamazaki, Kazuya Edamura, Yuko Koushige, Hisashi Shibuya, Emi Qian, Tsukika Sato, Junko Okahara, Noriyuki Kishi, Toshiaki Noce, Yoshifumi Yamaguchi, Hideyuki Okano
Step-by-step protocols for non-viral derivation of transgene-free induced pluripotent stem cells from somatic fibroblasts of multiple mammalian species. Development, growth & differentiation 64 (6) (2022)
Tao Lu, Munehisa Shinozaki, Narihito Nagoshi, Masaya Nakamura, Hideyuki Okano
3D imaging of supraspinal inputs to the thoracic and lumbar spinal cord mapped by retrograde tracing and light-sheet microscopy. Journal of neurochemistry 162 (4) (2022)
Satoshi Yokoi, Takuji Ito, Kentaro Sahashi, Masahiro Nakatochi, Ryoichi Nakamura, Genki Tohnai, Yusuke Fujioka, Shinsuke Ishigaki, Tsuyoshi Udagawa, Yuishin Izumi, Mitsuya Morita, Osamu Kano, Masaya Oda, Takefumi Sone, Hideyuki Okano, Naoki Atsuta, Masahisa Katsuno, Yohei Okada, Gen Sobue
The SYNGAP1 3'UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK. The Journal of neuroscience : the official journal of the Society for Neuroscience 42 (47) (2022)
Sho Yoshimatsu, Mayutaka Nakajima, Iki Sonn, Rie Natsume, Kenji Sakimura, Ena Nakatsukasa, Toshikuni Sasaoka, Mari Nakamura, Takashi Serizawa, Tsukika Sato, Erika Sasaki, Hongkui Deng, Hideyuki Okano
Attempts for deriving extended pluripotent stem cells from common marmoset embryonic stem cells. Genes to cells : devoted to molecular & cellular mechanisms 28 (2) (2022)
Hideyuki Okano
A combined stem-cell-gene therapy strategy for ALS. Nature medicine 28 (9) (2022)
Yoko Ozawa, Eriko Toda, Kohei Homma, Hideto Osada, Norihiro Nagai, Masayuki Ohta, Hideyuki Okano
Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa. Cells 11 (9) (2022)
Ryogen Sasaki, Satoru Morimoto, Fumiko Ozawa, Hideyuki Okano, Mari Yoshida, Hiroyuki Ishiura, Shoji Tsuji, Shigeki Kuzuhara, Yasumasa Kokubo
APOE Alleles With Tau and Aβ Pathology in Patients With Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex in the Kii Peninsula. Neurology 99 (22) (2022)
Sho Yoshimatsu, Mayutaka Nakajima, Iki Sonn, Rie Natsume, Kenji Sakimura, Ena Nakatsukasa, Toshikuni Sasaoka, Mari Nakamura, Takashi Serizawa, Tsukika Sato, Erika Sasaki, Hongkui Deng, Hideyuki Okano
Attempts for deriving extended pluripotent stem cells from common marmoset embryonic stem cells. Genes to cells : devoted to molecular & cellular mechanisms 28 (2) (2022)
Sho Yoshimatsu, Mayutaka Nakajima, Iki Sonn, Rie Natsume, Kenji Sakimura, Ena Nakatsukasa, Toshikuni Sasaoka, Mari Nakamura, Takashi Serizawa, Tsukika Sato, Erika Sasaki, Hongkui Deng, Hideyuki Okano
Attempts for deriving extended pluripotent stem cells from common marmoset embryonic stem cells. Genes to cells : devoted to molecular & cellular mechanisms (2022)
Syoichi Tashiro, Masaya Nakamura, Hideyuki Okano
Regenerative Rehabilitation and Stem Cell Therapy Targeting Chronic Spinal Cord Injury: A Review of Preclinical Studies. Cells 11 (4) (2022)
Kentaro Ago, Narihito Nagoshi, Kent Imaizumi, Takahiro Kitagawa, Momotaro Kawai, Keita Kajikawa, Reo Shibata, Yasuhiro Kamata, Kota Kojima, Munehisa Shinozaki, Takahiro Kondo, Satoshi Iwano, Atsushi Miyawaki, Masanari Ohtsuka, Haruhiko Bito, Kenta Kobayashi, Shinsuke Shibata, Tomoko Shindo, Jun Kohyama, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano
A non-invasive system to monitor in vivo neural graft activity after spinal cord injury. Communications biology 5 (1) (2022)
Kent Imaizumi, Hirosato Ideno, Tsukika Sato, Satoru Morimoto, Hideyuki Okano
Pathogenic Mutation of TDP-43 Impairs RNA Processing in a Cell Type-Specific Manner: Implications for the Pathogenesis of ALS/FTLD. eNeuro 9 (3) (2022)
Sho Yoshimatsu, Mayutaka Nakajima, Iki Sonn, Rie Natsume, Kenji Sakimura, Ena Nakatsukasa, Toshikuni Sasaoka, Mari Nakamura, Takashi Serizawa, Tsukika Sato, Erika Sasaki, Hongkui Deng, Hideyuki Okano
Attempts for deriving extended pluripotent stem cells from common marmoset embryonic stem cells. Genes to cells : devoted to molecular & cellular mechanisms (2022)
Sho Yoshimatsu, Mayutaka Nakajima, Emi Qian, Tsukasa Sanosaka, Tsukika Sato, Hideyuki Okano
Homologous Recombination-Enhancing Factors Identified by Comparative Transcriptomic Analyses of Pluripotent Stem Cell of Human and Common Marmoset. Cells 11 (3) (2022)
Woei-Yaw Chee, Yuriko Kurahashi, Junhyeong Kim, Kyoko Miura, Daisuke Okuzaki, Tohru Ishitani, Kentaro Kajiwara, Shigeyuki Nada, Hideyuki Okano, Masato Okada
β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells. Communications biology 4 (1) (2021)
Manami Deshimaru, Mariko Kinoshita-Kawada, Kaori Kubota, Takuya Watanabe, Yasuyoshi Tanaka, Saito Hirano, Fumiyoshi Ishidate, Masaki Hiramoto, Mitsuru Ishikawa, Yoshinari Uehara, Hideyuki Okano, Shinichi Hirose, Shinsuke Fujioka, Katsunori Iwasaki, Junichi Yuasa-Kawada, Takayasu Mishima, Yoshio Tsuboi
DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation. International journal of molecular sciences 22 (8) (2021)
Munehisa Shinozaki, Narihito Nagoshi, Masaya Nakamura, Hideyuki Okano
Mechanisms of Stem Cell Therapy in Spinal Cord Injuries. Cells 10 (10) (2021)
Makoto Hosoya, Masato Fujioka, Ayako Y Murayama, Kaoru Ogawa, Hideyuki Okano, Hiroyuki Ozawa
Dynamic Spatiotemporal Expression Changes in Connexins of the Developing Primate's Cochlea. Genes 12 (7) (2021)
Hirotaka Watanabe, Kent Imaizumi, Tetsuo Cai, Zhi Zhou, Taisuke Tomita, Hideyuki Okano
Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons. eNeuro 8 (2) (2021)
Norihiro Nagai, Hirohiko Kawashima, Eriko Toda, Kohei Homma, Hideto Osada, Naymel A Guzman, Shinsuke Shibata, Yasuo Uchiyama, Hideyuki Okano, Masayuki Ohta, Yoko Ozawa
Renin-angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models. Communications biology 3 (1) (2020)
Chika Saegusa, Makoto Hosoya, Takanori Nishiyama, Tsubasa Saeki, Chisato Fujimoto, Hideyuki Okano, Masato Fujioka, Kaoru Ogawa
Low-dose rapamycin-induced autophagy in cochlear outer sulcus cells. Laryngoscope investigative otolaryngology 5 (3) (2020)
Kent Imaizumi, Hideyuki Okano
Modeling neurodevelopment in a dish with pluripotent stem cells. Development, growth & differentiation 63 (1) (2020)
Toshiaki Teratani, Yohei Mikami, Nobuhiro Nakamoto, Takahiro Suzuki, Yosuke Harada, Koji Okabayashi, Yuya Hagihara, Nobuhito Taniki, Keita Kohno, Shinsuke Shibata, Kentaro Miyamoto, Harumichi Ishigame, Po-Sung Chu, Tomohisa Sujino, Wataru Suda, Masahira Hattori, Minoru Matsui, Takaharu Okada, Hideyuki Okano, Masayuki Inoue, Toshihiko Yada, Yuko Kitagawa, Akihiko Yoshimura, Mamoru Tanida, Makoto Tsuda, Yusaku Iwasaki, Takanori Kanai
The liver-brain-gut neural arc maintains the Treg cell niche in the gut. Nature 585 (7826) (2020)
Tomokazu Tsurugizawa, Kota Tamada, Nobukazu Ono, Sachise Karakawa, Yuko Kodama, Clément S Debacker, Junichi Hata, Hideyuki Okano, Akihiko Kitamura, Andrew Zalesky, Toru Takumi
Awake functional MRI detects neural circuit dysfunction in a mouse model of autism. Science advances 6 (6) (2020)
Nicolas Leventoux, Satoru Morimoto, Kent Imaizumi, Yuta Sato, Shinichi Takahashi, Kyoko Mashima, Mitsuru Ishikawa, Iki Sonn, Takahiro Kondo, Hirotaka Watanabe, Hideyuki Okano
Human Astrocytes Model Derived from Induced Pluripotent Stem Cells. Cells 9 (12) (2020)
Michael Heide, Christiane Haffner, Ayako Murayama, Yoko Kurotaki, Haruka Shinohara, Hideyuki Okano, Erika Sasaki, Wieland B Huttner
Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset. Science (New York, N.Y.) 369 (6503) (2020)
Seiko Harada, Yo Mabuchi, Jun Kohyama, Daisuke Shimojo, Sadafumi Suzuki, Yoshimi Kawamura, Daisuke Araki, Takashi Suyama, Masunori Kajikawa, Chihiro Akazawa, Hideyuki Okano, Yumi Matsuzaki
FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells. Stem cells (Dayton, Ohio) 39 (3) (2020)
Takumi Hirata, Yasumichi Arai, Shinsuke Yuasa, Yukiko Abe, Michiyo Takayama, Takashi Sasaki, Akira Kunitomi, Hiroki Inagaki, Motoyoshi Endo, Jun Morinaga, Kimio Yoshimura, Tetsuo Adachi, Yuichi Oike, Toru Takebayashi, Hideyuki Okano, Nobuyoshi Hirose
Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages. Nature communications 11 (1) (2020)
Akisa Nemoto, Reona Kobayashi, Sho Yoshimatsu, Andrew S Yoo, Takahiro Kondo, Andrew S Yoo, Seiji Shiozawa, Hideyuki Okano
Direct Neuronal Reprogramming of Common Marmoset Fibroblasts by ASCL1, microRNA-9/9*, and microRNA-124 Overexpression. Cells 10 (1) (2020)
Seiji Ishii, Toru Sasaki, Shahid Mohammad, Hye Hwang, Edwin Tomy, Fahad Somaa, Nobuyuki Ishibashi, Hideyuki Okano, Pasko Rakic, Kazue Hashimoto-Torii, Masaaki Torii
Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration. Proceedings of the National Academy of Sciences of the United States of America 118 (1) (2020)
Guoping Feng, Frances E Jensen, Henry T Greely, Hideyuki Okano, Stefan Treue, Angela C Roberts, James G Fox, Sarah Caddick, Mu-Ming Poo, William T Newsome, Danielle Beckman
Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research. Proceedings of the National Academy of Sciences of the United States of America 117 (39) (2020)
Hideyuki Okano, Douglas Sipp
New trends in cellular therapy. Development (Cambridge, England) 147 (18) (2020)
Yuji Tanimoto, Tomoteru Yamasaki, Narihito Nagoshi, Yuichiro Nishiyama, Satoshi Nori, Soraya Nishimura, Tsuyoshi Iida, Masahiro Ozaki, Osahiko Tsuji, Bin Ji, Ichio Aoki, Masahiro Jinzaki, Morio Matsumoto, Yasuhisa Fujibayashi, Ming-Rong Zhang, Masaya Nakamura, Hideyuki Okano
In vivo monitoring of remnant undifferentiated neural cells following human induced pluripotent stem cell-derived neural stem/progenitor cells transplantation. Stem cells translational medicine 9 (4) (2020)
Taro Tsujimura, Osamu Takase, Masahiro Yoshikawa, Etsuko Sano, Matsuhiko Hayashi, Kazuto Hoshi, Tsuyoshi Takato, Atsushi Toyoda, Hideyuki Okano, Keiichi Hishikawa
Controlling gene activation by enhancers through a drug-inducible topological insulator. eLife 9 (2020)
Wakako Kumita, Kenya Sato, Yasuhiro Suzuki, Yoko Kurotaki, Takeshi Harada, Yang Zhou, Noriyuki Kishi, Kengo Sato, Atsu Aiba, Yasubumi Sakakibara, Guoping Feng, Hideyuki Okano, Erika Sasaki
Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing. Scientific reports 9 (1) (2019)
Takashi Serizawa, Ayako Isotani, Takafumi Matsumura, Katsuyuki Nakanishi, Shigenori Nonaka, Shinsuke Shibata, Masahito Ikawa, Hideyuki Okano
Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers. Development (Cambridge, England) 146 (21) (2019)

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Hideyuki Okano