Longitudinal Associations Between MicroRNAs and Weight in the Diabetes Prevention Program.
Elena FlowersBenjamin M StroebelXingyue GongKimberly A LewisBradley E AouizeratMeghana GadgilAlka M KanayaLi ZhangPublished in: bioRxiv : the preprint server for biology (2024)
This study provided evidence for longitudinal relationships between circulating microRNAs and weight. Because microRNAs characterize the combined effects of genetic determinants and responses to behavioral determinants, they may provide insights about the etiology of overweight and obesity in the context or risk for common, complex diseases. Additional studies are needed to validate the potential genes and biological pathways that might be targeted by these microRNA biomarkers and have mechanistic implications for weight loss and disease prevention.
Keyphrases
- weight loss
- bariatric surgery
- roux en y gastric bypass
- genome wide
- glycemic control
- body mass index
- type diabetes
- physical activity
- weight gain
- cardiovascular disease
- gastric bypass
- cross sectional
- quality improvement
- dna methylation
- adipose tissue
- risk assessment
- copy number
- skeletal muscle
- metabolic syndrome
- case control