Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis.

Sijia LiuRomán González-PrietoMengdi ZhangPaul P GeurinkRaymond KooijPrasanna Vasudevan IyengarMaarten van DintherErik BosXiaobing ZhangSylvia E Le DévédecBob van de WaterRoman I KoningHong-Jian ZhuWilma E MeskerAlfred C O VertegaalHuib OvaaLong ZhangJohn W M MartensPeter Ten Dijke

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Our DUB activity profiling identified UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis and may provide a potential target for TNBC treatment.

Keyphrases

high glucose
diabetic rats
transforming growth factor
single cell
drug induced
oxidative stress
gene expression
genome wide
endothelial cells
young adults
signaling pathway