Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin.
Gwo-Yaw HoElizabeth L KyranJustin BedőMatthew J WakefieldDarren P EnnisHasan B MirzaCassandra J VandenbergElizabeth LieschkeAndrew FarrellAnthony HadlaRatana LimGenevieve DallJames E VinceNgee Kiat ChuaOlga KondrashovaRosanna Upstill-GoddardUlla-Maja BaileySuzanne DowsonPatricia RoxburghRosalind M GlasspoolGareth BrysonAndrew V Biankinnull nullSusanna L CookeGayanie RatnayakeOrla McNallyNadia Traficantenull nullAnna De FazioJohn S WerohaDavid D L BowtellIain A McNeishAnthony T PapenfussClare L ScottHolly E BarkerPublished in: Cancer research (2022)
Genomic analyses and preclinical models of ovarian carcinosarcoma support the conversion theory for disease development and indicate that microtubule inhibitors could be used to suppress EMT and stimulate antitumor immunity.