Enpp1 mutations promote upregulation of hedgehog signaling in heterotopic ossification with aging.
Zhongyuan HeZhengya ZhuTao TangFuan WangPeng GuoJianfeng LiNguyen Tran Canh TungQian LiangShaoyu LiuManMan GaoXizhe LiuZhiyu ZhouPublished in: Journal of bone and mineral metabolism (2024)
Our study indicated that with increasing age, mutations in Enpp1 promote ectopic ossification of spinal ligaments and endochondral ossification in tendons and further aggravate knee degeneration by upregulating hedgehog signaling.