The BEETS (JACCRO CC-18) trial: an observational and translational study of BRAF -mutated metastatic colorectal cancer.
Chiaki InagakiRyo MatobaSatoshi YukiManabu ShiozawaAkihito TsujiEisuke InoueKei MuroWataru IchikawaMasashi FujiiYu SunakawaPublished in: Future oncology (London, England) (2023)
For BRAF V600E-mutated metastatic colorectal cancer (mCRC), the BEACON phase 3 trial showed survival benefit of triplet therapy with cetuximab (anti-EGFR antibody), encorafenib (BRAF inhibitor) and binimetinib (MEK inhibitor) as well as doublet therapy with cetuximab and encorafenib over irinotecan-based chemotherapy plus anti-EGFR antibody. Both regimens are standards of care in Japan, but definite biomarkers for predicting efficacy and selecting treatment remain lacking. The mechanisms underlying resistance to these regimens also warrant urgent exploration to further evolve treatment. This prospective observational/translational study evaluated real-word clinical outcomes with cetuximab and encorafenib with or without binimetinib for BRAF -mutated mCRC patients and investigated biomarkers for response and resistance by collecting blood samples before and after treatment. Clinical Trial Registration: UMIN000045530 (https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000051983).
Keyphrases
- metastatic colorectal cancer
- clinical trial
- small cell lung cancer
- wild type
- healthcare
- end stage renal disease
- epidermal growth factor receptor
- study protocol
- tyrosine kinase
- chronic kidney disease
- newly diagnosed
- phase iii
- palliative care
- prognostic factors
- randomized controlled trial
- locally advanced
- replacement therapy
- pi k akt
- bone marrow
- signaling pathway
- smoking cessation
- single molecule