Co-expression of CD21L and IL17A defines a subset of rheumatoid synovia, characterised by large lymphoid aggregates and high inflammation.

Kelly J McKelveyMelanie J MillierTerence C DoyleLisa K StampJohn HightonPaul A Hessian

Published in: PloS one (2018)

Rheumatoid synovia can be subdivided on the basis of IL17A and CD21L gene expression. Ensuing molecular subgroups do not predict clinical outcome for patients but highlight high inflammation and the predominance of B-lymphocyte mediated mechanisms operating in IL17A+/CD21L+ synovia. This may provide a rationale for more refined therapeutic selection due to the distinct molecular profiles associated with IL17A+/CD21L+ and IL17A-/CD21L- rheumatoid synovia.

Keyphrases

gene expression
oxidative stress
nk cells
ejection fraction
clinical trial
rheumatoid arthritis patients
systemic lupus erythematosus
peripheral blood
long non coding rna
binding protein