Deep learning unmasks the ECG signature of Brugada syndrome.
Luke MeloGiuseppe CiconteAshton ChristyGabriele VicedominiLuigi AnastasiaCarlo PapponeEdward R GrantPublished in: PNAS nexus (2023)
One in 10 cases of sudden cardiac death strikes without warning as the result of an inherited arrhythmic cardiomyopathy, such as Brugada Syndrome (BrS). Normal physiological variations often obscure visible signs of this and related life-threatening channelopathies in conventional electrocardiograms (ECGs). Sodium channel blockers can reveal previously hidden diagnostic ECG features, however, their use carries the risk of life-threatening proarrhythmic side effects. The absence of a nonintrusive test places a grossly underestimated fraction of the population at risk of SCD. Here, we present a machine-learning algorithm that extracts, aligns, and classifies ECG waveforms for the presence of BrS. This protocol, which succeeds without the use of a sodium channel blocker (88.4% accuracy, 0.934 AUC in validation), can aid clinicians in identifying the presence of this potentially life-threatening heart disease.
Keyphrases
- machine learning
- deep learning
- heart rate variability
- heart rate
- artificial intelligence
- angiotensin converting enzyme
- case report
- randomized controlled trial
- heart failure
- pulmonary hypertension
- convolutional neural network
- palliative care
- big data
- genome wide
- blood pressure
- gene expression
- single cell
- atrial fibrillation