PGAM5 expression levels in heart failure and protection ROS-induced oxidative stress and ferroptosis by Keap1/Nrf2.

Shuangfei LiPing WenDayong ZhangDecai LiQidong GaoHong LiuYunfeng Di

Published in: Clinical and experimental hypertension (New York, N.Y. : 1993) (2023)

We conclude that the protection of PGAM5 reduced ROS-induced oxidative stress and ferroptosis by the Keap1/Nrf2 signaling pathway in heart failure, suggesting that targeting this mechanism of PGAM5 may be a feasible strategy to treat heart failure.

Keyphrases

heart failure
cell death
signaling pathway
oxidative stress
hydrogen peroxide
left ventricular
dna damage
acute heart failure
poor prognosis
cardiac resynchronization therapy
reactive oxygen species
pi k akt
protein protein
binding protein
nitric oxide
cell proliferation
long non coding rna
induced apoptosis