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LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway.

Xian-Zi YangTian-Tian ChengQing-Jun HeZi-Ying LeiJun ChiZhen TangQuan-Xing LiaoHong ZhangLi-Si ZengShu-Zhong Cui
Published in: Molecular cancer (2018)
Our findings suggest that reduced expression of LINC01133 is associated with aggressive tumor phenotypes and poor patient outcomes in GC. LINC01133 inhibits GC progression and metastasis by acting as a ceRNA for miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway, suggesting that LINC01133 may serve as a potential prognostic biomarker and anti-metastatic therapeutic target for GC.
Keyphrases
  • long non coding rna
  • poor prognosis
  • cell proliferation
  • long noncoding rna
  • stem cells
  • squamous cell carcinoma
  • small cell lung cancer
  • risk assessment
  • high resolution
  • liquid chromatography