The Expression of Toll-like Receptors in Cartilage Endplate Cells: A Role of Toll-like Receptor 2 in Pro-Inflammatory and Pro-Catabolic Gene Expression.

Tamara MengisLaura BernhardAndrea NüeschIrina HeggliNick HergerJan DevanRoy MarcusChristoph J Laux Florian BrunnerMazda FarshadOliver DistlerChristine L Le MaitreStefan Dudli

Published in: Cells (2024)

The expression of TLR1-10 in CEPCs suggests that the CEP is susceptible to PAMP and DAMP stimulation. Enhanced TLR2 expression in MC1, and generally in CEPCs under inflammatory conditions, has pro-inflammatory and pro-catabolic effects, suggesting a potential role in disc degeneration and MC.

Keyphrases

toll like receptor
poor prognosis
inflammatory response
gene expression
nuclear factor
immune response
binding protein
induced apoptosis
oxidative stress
cell death
cell cycle arrest