Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets.
Yasushi HorimasuNobuhisa IshikawaMasaya TaniwakiKakuhiro YamaguchiKosuke HamaiHiroshi IwamotoShinichiro OhshimoHironobu HamadaNoboru HattoriMorihito OkadaKoji ArihiroYuji OhtsukiNobuoki KohnoPublished in: BMC medical genetics (2017)
We identified several genes upregulated in chronic fibrosing IIP patients as compared to control, and found genes and pathways implicated in cancer, rather than in inflammatory or immunological disease to play important roles in the pathogenesis of IIPs. Moreover, DSG3 is a novel potential biomarker for chronic fibrosing IIP with its significantly high expression in IIP lung.
Keyphrases
- gene expression
- bioinformatics analysis
- end stage renal disease
- genome wide
- newly diagnosed
- interstitial lung disease
- ejection fraction
- chronic kidney disease
- dna methylation
- poor prognosis
- oxidative stress
- papillary thyroid
- squamous cell carcinoma
- rheumatoid arthritis
- risk assessment
- genome wide identification
- patient reported outcomes
- climate change
- human health