Combined Treatment of Heteronemin and Tetrac Induces Antiproliferation in Oral Cancer Cells.

Chi-Hung HuangTung-Yung HuangWong-Jin ChangYi-Shin PanHung-Ru ChuZi-Lin LiSukanya UnsonYu-Tang ChinChi-Yu LinHaw-Ming HuangChao-Nan HsiungFabio GionfraPaolo De VitoJens Zacho Pedersen Sandra IncerpiYi-Ru ChenSheng-Yang LeeHung-Yun LinPaul J DavisJacqueline Whang-PengKuan Wang

Published in: Marine drugs (2020)

Both heteronemin and tetrac inhibited ERK1/2 activation and increased p53 phosphorylation. They also inhibited THBS-1 expression. Moreover, tetrac suppressed TGF-β expression combined with heteronemin to further enhance antiproliferation and anti-metastasis in oral cancer cells.

Keyphrases

poor prognosis
signaling pathway
binding protein
cell proliferation
long non coding rna
pi k akt
replacement therapy