CD47 Expression in Circulating Tumor Cells and Circulating Tumor Microemboli from Non-Small Cell Lung Cancer Patients Is a Poor Prognosis Factor.
Jacqueline Aparecida TorresAngelo Borsarelli Carvalho BritoVirgilio Souza E SilvaIara Monique MessiasAlexcia Camila BraunAnna Paula Carreta RuanoMarcilei E C BuimDirce Maria CarraroLudmilla Thomé Domingos ChinenPublished in: International journal of molecular sciences (2023)
In this study, we observed that CTC/CTM from NSCLC patients express the immune evasion markers TGFβRI/CD47. The presence of CTMs CD47+ is associated with poor PFS. This was the first study to investigate CD47 expression in CTCs/CTM of patients with NSCLC and its association with poor PFS.
Keyphrases
- poor prognosis
- circulating tumor cells
- circulating tumor
- long non coding rna
- small cell lung cancer
- end stage renal disease
- nk cells
- chronic kidney disease
- ejection fraction
- advanced non small cell lung cancer
- mesenchymal stem cells
- prognostic factors
- tyrosine kinase
- epithelial mesenchymal transition
- patient reported
- patient reported outcomes