Electroacupuncture attenuates ac4C modification of P16 mRNA in the ovarian granulosa cells of a mouse model premature ovarian failure.

Zixiang GengPeng LiuLong YuanKaiyong ZhangJiajia LinXiaoli NieHuiru JiangBingrong LiTe LiuBimeng Zhang

Published in: Acupuncture in medicine : journal of the British Medical Acupuncture Society (2022)

This study demonstrated that EA promoted the repair of the ovarian microenvironment by inhibiting the ac4C modification of P16 mRNA to decrease its stability and expression intensity, and by altering the activity of the P16/CDK6/CCND1 axis in OGCs.

Keyphrases

mouse model
binding protein
induced apoptosis
poor prognosis
stem cells
cell cycle
high intensity
neuropathic pain
oxidative stress
endoplasmic reticulum stress
adipose tissue
polycystic ovary syndrome
spinal cord injury
metabolic syndrome
spinal cord
cell death