Exploring the Mechanism of Edaravone for Oxidative Stress in Rats with Cerebral Infarction Based on Quantitative Proteomics Technology.
Guozuo WangXiaomei ZengShengqiang GongShanshan WangAnqi GeWenlong LiuJin-Wen GeQi HePublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
The therapeutic mechanism of edaravone in the treatment of CI may involve platelet activation and aggregation, oxidative stress, intercellular adhesion, glycolysis and gluconeogenesis, iron metabolism, hypoxia, and so on. This study revealed the serum protein profile of edaravone in the treatment of cerebral infarction rats through serum TMT proteomics and discovered the relevant mechanism of edaravone regulating iron metabolism in cerebral infarction, which provides new ideas for the study of edaravone intervention in cerebral infarction and also provides reference information for future research on the mechanism of edaravone intervention in iron metabolism-related diseases.
Keyphrases
- oxidative stress
- randomized controlled trial
- mass spectrometry
- dna damage
- healthcare
- ischemia reperfusion injury
- endothelial cells
- escherichia coli
- induced apoptosis
- social media
- staphylococcus aureus
- endoplasmic reticulum stress
- biofilm formation
- signaling pathway
- candida albicans
- cell migration
- smoking cessation
- heat shock