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Endogenous stimulation is responsible for the high frequency of IL-17A-producing neutrophils in patients with rheumatoid arthritis.

Maria Gonzalez-OrozcoRosa E Barbosa-CobosPaola Santana-SanchezLizbeth Becerril-MendozaLeonardo Limon-CamachoAna I Juarez-EstradaGustavo E Lugo-ZamudioJose Moreno-RodriguezVianney Francisco Ortiz-Navarrete
Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2019)
IL-17A-producing neutrophils are increased in some RA patients, which are not related to disease activity but have an increased frequency in patients with recent-onset disease. This finding suggests that IL-17A-producing neutrophils play an early role in the development of RA.
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