Astaxanthin protects astrocytes against trauma-induced apoptosis through inhibition of NKCC1 expression via the NF-κB signaling pathway.

Mingkun ZhangZhenwen CuiHua CuiYong WangChunlong Zhong

Published in: BMC neuroscience (2017)

ATX attenuates apoptosis after stretch injury in cultured astrocytes by inhibiting NKCC1 expression, and it acts by reducing the expression of NF-κB-mediated pro-inflammatory factors.

Keyphrases

signaling pathway
induced apoptosis
poor prognosis
oxidative stress
pi k akt
endoplasmic reticulum stress
epithelial mesenchymal transition
cell cycle arrest
binding protein
cell death
long non coding rna
immune response
endothelial cells
cell proliferation