Assessment of immune responses to a Comirnaty® booster following CoronaVac® vaccination in healthcare workers.
Lucas Bochnia-BuenoGabriela Mattoso CoelhoAllan Henrique Depieri CataneoCamila ZanlucaLaura Holtman FerreiraLuciano Pamplona de Goes CavalcantiMarco Antonio de Freitas ClementinoJuliana Navarro Ueda YaochiteHellen Geremias Dos SantosMeri Bordignon NogueiraClaudia N Duarte Dos SantosSonia Maria RaboniPublished in: Memorias do Instituto Oswaldo Cruz (2024)
The neutralisation titres in the T2 samples decreased, and antibody levels detected at T2 showed a more significant reduction than the neutralisation. The higher IL-22 expression in immunised individuals compared to those with COVID-19 suggests that IL-22 may be beneficial in protecting against severe disease.