Immunohistochemical biomarker validation in highly selective needle biopsy microarrays derived from mpMRI-characterized prostates.

Jonathan OlivierVasilis StavrinidesJonathan KayAlex FreemanHayley PyeZeba AhmedLina Carmona EcheverriaSusan HeaveyLucy A M SimmonsAbi KanthabalanManit AryaTim BriggsDean BarrattSusan C CharmanJames GelisterDavid HawkesYipeng HuCharles JamesonNeil McCartanShonit PunwaniJan van der MuelenCaroline MooreMark EmbertonHashim U AhmedHayley C Whitaker

Published in: The Prostate (2018)

The construction of highly selective TMAs from prostate needle biopsy cores is possible. IHC data obtained through this method are highly reliable and can be correlated with imaging. IHC expression patterns for PSA, PSMA, AMACR, p63, and MSMB are distinct in malignant and adjacent benign tissue but did not correlate with mpMRI Likert score.

Keyphrases

ultrasound guided
prostate cancer
fine needle aspiration
benign prostatic hyperplasia
poor prognosis
pet ct
high resolution
electronic health record
pet imaging
big data
binding protein
fluorescence imaging
mass spectrometry
data analysis