Topical cutaneous application of carbon dioxide via a hydrogel for improved fracture repair: results of phase I clinical safety trial.

Takahiro NiikuraTakashi IwakuraTakashi OmoriSang Yang LeeYoshitada SakaiToshihiro AkisueKeisuke OeTomoaki FukuiTakehiko MatsushitaTomoyuki MatsumotoRyosuke Kuroda

Published in: BMC musculoskeletal disorders (2019)

This study has been registered in the UMIN Clinical Trials Registry (Registration number: UMIN000013641, Date of registration: July 1, 2014).

Keyphrases

carbon dioxide
clinical trial
phase ii
phase iii
drug delivery
wound healing
study protocol
randomized controlled trial
open label
placebo controlled