Explaining why childhood abuse is a risk factor for poorer clinical course in bipolar disorder: a path analysis of 923 people with bipolar I disorder.

Steven MarwahaPaul M BrileyAmy PerryPhillip RankinArianna DiFlorioNick CraddockIan JonesMatthew BroomeKatherine Gordon-SmithLisa Jones

Published in: Psychological medicine (2019)

Affective instability and impulsivity are likely part of the mechanism of why childhood abuse increases risk of poorer clinical course in bipolar disorder, with each showing some selectivity in pathways. They are potential novel targets for intervention to improve outcome in bipolar disorder.

Keyphrases

bipolar disorder
major depressive disorder
randomized controlled trial
early life
intimate partner violence
obsessive compulsive disorder
risk assessment
climate change