Impact of Expression and Genetic Variation of microRNA-34b/c on Cognitive Dysfunction in Patients with Major Depressive Disorder.

Ning SunChunxia YangXiaoting HeZhifen LiuSha LiuXinrong LiYanfang WangRuihua JinKerang Zhang

Published in: Neuropsychiatric disease and treatment (2020)

Our findings suggest that changes in miR-34c expression level have important impacts on cognitive function in patients with MDD. In particular, the polymorphism rs2187473 is a potential genetic risk factor for cognitive function in MDD, which may be of clinical use.

Keyphrases

major depressive disorder
bipolar disorder
poor prognosis
long non coding rna
cell proliferation
long noncoding rna
gene expression
copy number
risk assessment