Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism.
Adriana S A PereiraMurilo Sena AmaralElton J R VasconcelosDavid S PiresHuma AsifLucas F daSilvaDavid A Morales-VicenteVitor C CarneiroClaudia B AngeliGiuseppe PalmisanoMarcelo R FantappieRaymond J PierceJoão C SetubalSergio Verjovski-AlmeidaPublished in: PLoS neglected tropical diseases (2018)
The results indicated that GSK343 presents in vitro activities against S. mansoni, and the characterization of EZH2 as a new potential molecular target establishes EZH2 inhibitors as part of a promising new group of compounds that could be used for the development of schistosomicidal agents.