Mesenchymal stem cells and thermal annular procedures for discogenic pain: a systematic review with pooled analysis.
John DesRochersRyan DesRochersDev PatelCassidy AndruszkaShikhar ManchandaAkhmad ErnazarovAleesa MobleyPublished in: Pain management (2024)
Aim: Compare the effectiveness of mesenchymal stem cell injection therapies (MSC) and thermal annular procedures for the treatment of discogenic lower back pain. Materials & methods: A systematic review was performed following PRISMA 2020 guidelines. Pooled analysis was performed using patients' pain scores at baseline and at 12 months post-intervention. Results: Effect sizes based on change in pain score from baseline to 12 month follow-up revealed clinically significant improvement in pain score across all interventions. Conclusion: Minimally invasive interventions provide meaningful relief in discogenic back pain, with results suggesting promise for MSC injection therapies as a treatment model.
Keyphrases
- chronic pain
- mesenchymal stem cells
- pain management
- neuropathic pain
- minimally invasive
- randomized controlled trial
- physical activity
- bone marrow
- ejection fraction
- systematic review
- end stage renal disease
- umbilical cord
- spinal cord injury
- newly diagnosed
- ultrasound guided
- single cell
- machine learning
- cell therapy
- patient reported outcomes
- clinical practice
- big data
- patient reported