Nonnutritive sweetener consumption during pregnancy, adiposity, and adipocyte differentiation in offspring: evidence from humans, mice, and cells.

Meghan B AzadAlyssa ArchibaldMateusz M TomczykAlanna HeadKyle G CheungRussell J de SouzaAllan B BeckerPiushkumar J MandhaneStuart E TurveyTheo J MoraesMalcolm R SearsPadmaja SubbaraoVernon W Dolinsky

Published in: International journal of obesity (2005) (2020)

By triangulating evidence from humans, mice, and cultured adipocytes, this study provides new evidence that maternal NNS consumption during pregnancy may program obesity risk in offspring through effects on adiposity and adipocyte differentiation.

Keyphrases

insulin resistance
high fat diet induced
high fat diet
adipose tissue
metabolic syndrome
skeletal muscle
type diabetes
induced apoptosis
cell cycle arrest
endothelial cells
quality improvement
oxidative stress
fatty acid
physical activity
cell death
pregnant women
signaling pathway
cell proliferation