A non-inferiority clinical trial comparing probiotics and oral corticosteroids for the management of acute exacerbation of atopic dermatitis patients.
Nahla A GamalMohammed A ShoaibAzza G FaragRichard StarkSimon TsoPublished in: Skin health and disease (2024)
A prospective controlled pilot study on the feasibility of utilization of a probiotic mixture for management of acute exacerbation of atopic dermatitis (AD). Patients were allocated to either standard of care (SOC) therapy with tapering dose of steroids or a probiotic mixture over 3 weeks. After the 3-week intervention, patients on steroids achieved significantly higher clinical response rates and significantly deeper response as measured by the change in SCORAD score. No gut microbiome changes could be appreciated in either group after the treatment period. We could conclude that probiotics cannot replace SOC therapy for the management of acute exacerbation of AD.
Keyphrases
- end stage renal disease
- clinical trial
- newly diagnosed
- atopic dermatitis
- ejection fraction
- chronic obstructive pulmonary disease
- liver failure
- chronic kidney disease
- respiratory failure
- randomized controlled trial
- peritoneal dialysis
- healthcare
- prognostic factors
- intensive care unit
- stem cells
- drug induced
- hepatitis b virus
- phase ii
- extracorporeal membrane oxygenation
- smoking cessation
- patient reported
- preterm birth
- replacement therapy