DBN-Mediated Addition Reaction of α-(Trifluoromethyl)styrenes with Diazoles, Triazoles, Tetrazoles, and Primary, Secondary, and Secondary Cyclic Amines.

A mild and efficient DBN-mediated addition reaction of α-(trifluoromethyl)styrenes with diazoles, triazoles, tetrazoles, and primary, secondary, and secondary cyclic amines was developed. This practical protocol provided a robust method for the synthesis of various β-trifluoromethyl nitrogen-containing heterocycles and β-trifluoromethyl amines.