Diabetes concomitant to aortic stenosis is associated with increased expression of NF-κB and more pronounced valve calcification.
Magdalena KopytekPiotr K MazurMichał Tomasz ZąbczykAnetta UndasJoanna NatorskaPublished in: Diabetologia (2021)
Type 2 diabetes enhances in loco inflammation and coagulation activation within stenotic valve leaflets. Increased valvular expression of NF-κB in diabetic individuals is associated not only with serum HbA1c and fructosamine levels but also with AVA and transvalvular gradient, indicating that strict long-term glycaemic control is needed in AS patients with concomitant type 2 diabetes. This study suggests that maintaining these variables within the normal range may slow the rate of AS progression.
Keyphrases
- type diabetes
- aortic stenosis
- aortic valve
- transcatheter aortic valve replacement
- ejection fraction
- aortic valve replacement
- transcatheter aortic valve implantation
- glycemic control
- poor prognosis
- left ventricular
- signaling pathway
- oxidative stress
- lps induced
- cardiovascular disease
- insulin resistance
- coronary artery disease
- mitral valve
- pi k akt
- nuclear factor
- long non coding rna
- atrial fibrillation
- inflammatory response
- binding protein
- metabolic syndrome
- skeletal muscle