S100A11/ANXA2 belongs to a tumour suppressor/oncogene network deregulated early with steatosis and involved in inflammation and hepatocellular carcinoma development.

Cyril SobolewskiDaniel AbeggFlavien BerthouDobrochna DolickaNicolas CaloChristine SempouxMargot FournierChristine MaederAnne-Sophie AyPierre-Alain ClavienBostjan HumarJean-François DufourAlexander AdibekianMichelangelo Foti

Published in: Gut (2020)

Cellular stress associated with NAFLD triggers non-genomic alterations of a whole network of TSs/ONCs fostering hepatocarcinogenesis. Among those, overexpression of the oncogenic factor S100A11 promotes inflammation/fibrosis in vivo and is significantly associated with high-grade HCC with poor prognosis.

Keyphrases

poor prognosis
high grade
long non coding rna
oxidative stress
transcription factor
low grade
insulin resistance
cell proliferation
copy number
gene expression
liver fibrosis
skeletal muscle
network analysis
heat stress