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Stereoselective Synthesis of Highly Substituted O-Heterocycles via Matteson Homologation: A Ring-Closing Metathesis Approach.

Thorsten KinsingerPatrick SchäferUli Kazmaier
Published in: Organic letters (2023)
Matteson homologations of chiral boronic esters with the aid of unsaturated nucleophiles are powerful for gaining access to a range of different O-heterocycles via subsequent ring-closing metatheses. Using this protocol, six- to eight-membered rings become available and almost any position of the ring can be substituted and/or functionalized.
Keyphrases
  • molecular docking
  • randomized controlled trial
  • quantum dots
  • ionic liquid
  • high resolution
  • capillary electrophoresis
  • molecular dynamics simulations