Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity.

Stephanie M LinkerLara UrbanStephen J ClarkMariya ChhatriwalaShradha AmatyaDavis J McCarthyIngo EbersbergerLudovic VallierWolf ReikOliver StegleMarc Jan Bonder

Published in: Genome biology (2019)

Our study yields new insights into alternative splicing at the single-cell level and reveals a previously underappreciated link between DNA methylation variation and splicing.

Keyphrases

single cell
dna methylation
rna seq
high throughput
genome wide
gene expression
poor prognosis
binding protein