Functionalized gold nanostructures: promising gene delivery vehicles in cancer treatment.
Sanjay KumarAnchita DiwanParinita SinghShikha GulatiDevanshu ChoudharyAyush MongiaShefali ShuklaAkanksha GuptaPublished in: RSC advances (2019)
Surface-modified gold nanoparticles are recognized as promising gene delivery vehicles in the treatment of cancer owing to their excellent biocompatibility with biomolecules (like DNA or RNA) and their unique optical and structural properties. In this context, this review article focuses on the diverse transfection abilities of the gene to the targeted cell on the basis of different shapes and sizes of gold nanoparticles in order to promote its effective expression for cancer treatment. In addition, recent trends in gold nanoparticle mediated gene silencing, gene delivery, detection and combinatory therapies are highlighted considering their cytotoxic effects on healthy human cells.
Keyphrases
- gold nanoparticles
- reduced graphene oxide
- poor prognosis
- papillary thyroid
- single cell
- cell therapy
- high resolution
- circulating tumor
- genome wide
- copy number
- cell free
- cancer therapy
- squamous cell
- nucleic acid
- quantum dots
- single molecule
- stem cells
- squamous cell carcinoma
- label free
- dna methylation
- binding protein
- real time pcr
- bone marrow
- long non coding rna
- transcription factor
- molecularly imprinted
- genome wide analysis