Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome.
Antonella NotarnicolaCharlotta PregerSusanna L LundströmNuria RenardEdvard WigrenEveline Van GompelAngeles S Galindo-FeriaHelena PerssonMaryam FathiJohan GrunewaldPer-Johan JakobssonSusanne GräslundIngrid E LundbergCátia Fernandes-CerqueiraPublished in: Arthritis research & therapy (2022)
High levels and high-affinity anti-Jo1 autoantibodies towards HisRS-FL were found early in disease in sera and BALF. In combination with the correlation of anti-HisRS-FL antibody levels with ILD and ILD activity in longitudinal samples as well as of anti-WHEP IgG in BALF with poor pulmonary function, this supports the previously raised hypothesis that the lung might have a role in the immune reaction in anti-Jo1-positive patients.