PD-L1 is a double-edged sword in colorectal cancer: the prognostic value of PD-L1 depends on the cell type expressing PD-L1.
Hsiang-Ling HoTeh-Ying ChouShung-Haur YangJeng-Kai JiangWei-Shone ChenYee ChaoHao-Wei TengPublished in: Journal of cancer research and clinical oncology (2019)
PD-L1-expressing TCs were a marker of poor prognosis; in contrast, PD-L1-expressing TIICs were a marker of good prognosis. The MSI-H phenotype was associated with the presence of PD-L1-expressing TIICs, but not of PD-L1-expressing TCs.