Association of HLA-DRB1 Alleles with Rheumatic Fever and Rheumatic Heart Disease: A Meta-analysis.

Maheshkumar PoomarimuthuThirunavukkarasu RamasamyRamajayam GovindanRathinavel AndiappanGunavathy NagarajanSony KadiamJayalakshmi Mariakuttikan

Published in: Immunological investigations (2020)

The results of the meta-analysis suggest that the differential presentation of autoimmune peptides by HLA-DRB1*07 (susceptible) and HLA-DRB1*15 (protective) alleles with different affinities may play a crucial role in the pathogenesis of RF/RHD.

Keyphrases

systematic review
rheumatoid arthritis
multiple sclerosis
pulmonary hypertension
randomized controlled trial
drug induced