The Proximal Airway Is a Reservoir for Adaptive Immunologic Memory in Idiopathic Subglottic Stenosis.
Alexander GelbardCelestine WanjallaChristopher T WoottenWonder P DrakeAnne S LoweryDavid A WheelerMaria F CardenasAndrew G SikoraRavi R PathakWyatt McDonnellSimon MallalMark PilkintonPublished in: The Laryngoscope (2020)
The human subglottis is significantly enriched for CD8+ tissue resident memory T cells in iSGS, which possess TCR sequences proven to recognize viral and intracellular pathogens. These results inform our understanding of iSGS, provide a direction for future discovery, and demonstrate immunologic function in the human proximal airway. Laryngoscope, 131:610-617, 2021.