Generation of multilineage liver organoids with luminal vasculature and bile ducts from human pluripotent stem cells via modulation of Notch signaling.

Hyo Jin KimGyeongmin KimKyun Yoo ChiHyemin KimYu Jin JangSeongyea JoJihun LeeYoungseok LeeDong-Hun WooChoongseong HanSang Kyum KimHan-Jin ParkJong-Hoon Kim

Published in: Stem cell research & therapy (2023)

Our results demonstrate that mLOs can reproduce parenchymal and non-parenchymal cell interactions and suggest that their application can advance the precise modeling of liver diseases in vitro.

Keyphrases

pluripotent stem cells
endothelial cells
single cell
cell therapy
mesenchymal stem cells
stem cells
bone marrow