ABHD5-A Regulator of Lipid Metabolism Essential for Diverse Cellular Functions.
Margarita SchratterAchim LassFranz P W RadnerPublished in: Metabolites (2022)
The α/β-Hydrolase domain-containing protein 5 ( ABHD5 ; also known as comparative gene identification-58, or CGI-58) is the causative gene of the Chanarin-Dorfman syndrome (CDS), a disorder mainly characterized by systemic triacylglycerol accumulation and a severe defect in skin barrier function. The clinical phenotype of CDS patients and the characterization of global and tissue-specific ABHD5-deficient mouse strains have demonstrated that ABHD5 is a crucial regulator of lipid and energy homeostasis in various tissues. Although ABHD5 lacks intrinsic hydrolase activity, it functions as a co-activating enzyme of the patatin-like phospholipase domain-containing (PNPLA) protein family that is involved in triacylglycerol and glycerophospholipid, as well as sphingolipid and retinyl ester metabolism. Moreover, ABHD5 interacts with perilipins (PLINs) and fatty acid-binding proteins (FABPs), which are important regulators of lipid homeostasis in adipose and non-adipose tissues. This review focuses on the multifaceted role of ABHD5 in modulating the function of key enzymes in lipid metabolism.
Keyphrases
- fatty acid
- transcription factor
- quantum dots
- end stage renal disease
- gene expression
- signaling pathway
- copy number
- adipose tissue
- ejection fraction
- insulin resistance
- escherichia coli
- newly diagnosed
- binding protein
- genome wide
- chronic kidney disease
- prognostic factors
- protein protein
- metabolic syndrome
- early onset
- peritoneal dialysis
- drug induced
- dna methylation
- small molecule
- genome wide identification
- skeletal muscle
- patient reported