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Interpreting a Bayesian phase II futility clinical trial.

Jonathan BeallChristy CassarlyRenee Martin
Published in: Trials (2022)
Phase II futility clinical trials, when designed under in a Bayesian framework, offer an alternative approach to the design of mid-phase studies which provide unique benefits relative to trials designed in a frequentist framework and designs which focus on treatment efficacy.
Keyphrases
  • phase ii
  • clinical trial
  • open label
  • double blind
  • phase iii
  • study protocol
  • placebo controlled
  • randomized controlled trial
  • combination therapy
  • replacement therapy
  • finite element analysis