Aspirin prevents NF-κB activation and CDX2 expression stimulated by acid and bile salts in oesophageal squamous cells of patients with Barrett's oesophagus.
Xiaofang HuoXi ZhangChunhua YuEdaire ChengQiuyang ZhangKerry B DunbarThai H PhamJohn P LynchDavid H WangRobert S BresalierStuart J SpechlerRhonda F SouzaPublished in: Gut (2017)
Differences between NES-B and NES-G cells in NF-κB activation by acid and bile salts can account for their differences in CDX2 expression, and their CDX2 expression can be blocked by aspirin. These findings might explain why some patients with GORD develop Barrett's oesophagus while others do not, and why aspirin might protect against development of Barrett's oesophagus.
Keyphrases
- poor prognosis
- induced apoptosis
- low dose
- signaling pathway
- cell cycle arrest
- cardiovascular events
- antiplatelet therapy
- pi k akt
- oxidative stress
- lps induced
- ionic liquid
- endoplasmic reticulum stress
- type diabetes
- high grade
- immune response
- mouse model
- acute coronary syndrome
- cell death
- coronary artery disease
- cell proliferation
- percutaneous coronary intervention
- toll like receptor