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Gastric Burkitt's monomorphic post-transplant lymphoproliferative disorder after kidney transplantation: A case report.

Yusuke YoshimuraTatsuya SuwabeArisa FujikiDaisuke KajiYuki Asano-MoriYuki ObaHiroki MizunoMasayuki YamanouchiKiho TanakaEiko HasegawaKatsuyuki MikiTakayoshi YokoyamaYuki NamamuraYasuo IshiiSatoshi YamashitaKei KonoKeiichi KinowakiYutaka TakazawaNaoki SawaYoshifumi Ubara
Published in: Clinical nephrology (2024)
We report on a 53-year-old Japanese man diagnosed with gastric Burkitt's monomorphic post-transplant lymphoproliferative disorder (B-PTLD) after endoscopy for gastric discomfort 28 months after the patient underwent renal transplantation in Ethiopia. Serum Epstein-Barr virus (EBV) tests were negative before transplantation, but the tumor cells collected from a gastric biopsy showed positive EBV-encoded small RNAs (EBER) at B-PTLD onset. Intensive treatment started with R(rituximab)-CHOP therapy and continued with DA-EPOCH-R therapy has been effective, and relapse has not yet occurred. Burkitt lymphoma has a poor prognosis, but B-PTLD may be effectively treated with high-dose chemotherapy. This is a rare case of gastric B-PTLD in a Japanese patient.
Keyphrases
  • epstein barr virus
  • diffuse large b cell lymphoma
  • poor prognosis
  • high dose
  • rare case
  • long non coding rna
  • case report
  • low dose
  • mesenchymal stem cells
  • ultrasound guided