Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system.
Luca LiberaleAlexander AkhmedovNikolaos I VlachogiannisNicole R BonettiVanasa NageswaranMelroy X MirandaYustina M PuspitasariLena SchwarzSarah CostantinoFrancesco PaneniJürg H BeerFrank RuschitzkaFabrizio MontecuccoThomas F LüscherKimon StamatelopoulosKonstantinos StellosGiovanni G CamiciPublished in: Cardiovascular research (2022)
SIRT5 promotes arterial thrombosis by modulating fibrinolysis through endothelial PAI-1 expression. Hence, SIRT5 may be an interesting therapeutic target in the context of atherothrombotic events.