Towards multiomics-based dissection of anti-EGFR sensitivity in colorectal cancer.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Over-expression of the EGFR ligands AREG/EREG may be a surrogate of EGFR dependency regardless of sidedness in mCRC. High AREG/EREG may be coupled with negative hyper-selection (i.e. lack of genomic drivers of primary resistance beyond RAS and BRAF) to identify patients with right-sided tumors and potential sensitivity to EGFR blockade.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
poor prognosis
gene expression
wild type
risk assessment
human health
long non coding rna
dna methylation
climate change
binding protein
genome wide