Diabetic cardiomyopathy (DCM), a significant complication of diabetes mellitus, is marked by myocardial structural and functional alterations due to chronic hyperglycemia. Despite its clinical significance, optimal treatment strategies are still elusive. Bariatric surgery via sleeve gastrectomy and Roux-en-Y gastric bypass have shown promise in treating morbid obesity and associated metabolic disorders including improvements in diabetes mellitus and DCM. The present study reviews the molecular mechanisms by which bariatric surgery improves DCM, offering insights into potential therapeutic targets. Future research should further investigate the mechanistic links between bariatric surgery and DCM, to evaluate the benefits and limitations of these surgical interventions for DCM treatment. The present study aims to provide a foundation for more effective DCM therapies, contributing to the advancement of patient care.
Keyphrases
- bariatric surgery
- weight loss
- obese patients
- roux en y gastric bypass
- gastric bypass
- type diabetes
- glycemic control
- heart failure
- physical activity
- randomized controlled trial
- metabolic syndrome
- systematic review
- body mass index
- insulin resistance
- machine learning
- left ventricular
- climate change
- deep learning
- adipose tissue
- current status
- weight gain
- combination therapy
- meta analyses