Targeting RNA-binding proteins in acute and chronic leukemia.
Irina A ElchevaVladimir S SpiegelmanPublished in: Leukemia (2020)
RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant expression of alternatively spliced, modified, and stabilized mRNA transcripts is essential to self-renewal, proliferation, and adaptation to stress. In this review, we assess the impact of key families of RBPs in leukemogenesis, review progress in targeting those proteins with small molecules, and discuss how multilevel composition of posttranscriptional regulation of gene expression could be used for potential therapies in acute and chronic leukemia.
Keyphrases
- gene expression
- liver failure
- drug induced
- respiratory failure
- acute myeloid leukemia
- bone marrow
- poor prognosis
- cancer therapy
- nucleic acid
- aortic dissection
- dna methylation
- papillary thyroid
- signaling pathway
- binding protein
- hepatitis b virus
- bone mineral density
- squamous cell
- drug delivery
- long non coding rna
- climate change
- body composition
- risk assessment
- human health