A phase I-II controlled randomized trial using a promising novel cell-free formulation for articular cartilage regeneration as treatment of severe osteoarthritis of the knee.
Iván Delgado-EncisoJuan Paz-GarciaJose Valtierra-AlvarezJorge Preciado-RamirezRoman Almeida-TrinidadJose Guzman-EsquivelMartha A Mendoza-HernandezAlberto Garcia-VegaAlejandro D Soriano-HernandezJose L Cortes-BazanHector R Galvan-SalazarAriana Cabrera-LiconaIram P Rodriguez-SanchezMargarita L Martinez-FierroJosuel Delgado-EncisoBrenda Paz-MichelPublished in: European journal of medical research (2018)
The intra-articular application of the new bioactive cell-free formulation (BIOF2) was well tolerated and showed no significative differences with arthroplasty for the treatment of severe osteoarthritis of the knee. BIOF2 can regenerate articular cartilage and is an easily implemented alternative therapy for the treatment of osteoarthritis. Trial registration Cuban Public Registry of Clinical Trials (RPCEC) Database RPCEC00000250. Registered 08/15/2017-Retrospectively registered, http://rpcec.sld.cu/en/trials/RPCEC00000250-En .