Suppression of CD81 promotes bladder cancer cell invasion through increased matrix metalloproteinase expression via extracellular signal-regulated kinase phosphorylation.

Hyun Sik ParkSuhyuk LeeJisu LeeHyun Bin ShinSeung-Min YooMyung-Shin LeeJinsung Park

Published in: Investigative and clinical urology (2019)

Taken together, CD81 suppression promotes the invasive property of BC cells through MMP signaling via ERK phosphorylation. Our results suggest that the regulation of CD81 expression may have some therapeutic potential in BC.

Keyphrases

poor prognosis
protein kinase
induced apoptosis
nk cells
signaling pathway
cell proliferation
cell cycle arrest
transcription factor
binding protein
pi k akt
cell death
oxidative stress
cell migration